The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.
The ideal candidate will be an expert in UX/UI design and back-end development of web applications to help scientists visualize, analyze and understand high-dimensional biological data. You will have a strong background in computer science, web development, bioinformatics, or computational biology and truly exceptional skills in designing visualizations to render complex, multi-dimensional biological data interpretable and understandable. You should be able to present or provide links to a strong work portfolio that demonstrates your expertise in designing, building, and deploying insightful web-based applications. You will be a team player and will work as part of an interdisciplinary team of 40 scientists including biochemists, NMR spectroscopists, data scientists and bioinformaticians. Exceptional communication (written and verbal) and critical thinking skills are a must.
When submitting your application, please include your CV and a cover letter, which includes information or a link to a portfolio of past projects. If you do not meet the minimum years’ experience for your degree level, but believe you are a truly exceptional candidate, please contact Ben Leslie ([email protected]) for more information.
Preferred Skills and Experience:
Exceptionally strong background and skills in the development of web sites and applications
Expertise working with biological data (structural data, sequences, expression, network, genomic data, etc.) or a strong willingness to acquire the required knowledge
Proven expertise in successfully deploying web applications to internal or public-facing networks
A strong understanding and ability to work with SQL datasets, and familiarity with next-gen ORMs that abstract these data types (e.g., SQLAlchemy, GraphQL, Prisma, Apollo, etc.)
Strong proficiency with the different cloud services (e.g., AWS, Azure, Google Cloud) as well as hybrid cloud technologies
Strong adherence to using version control software, functionality testing, reviewing and debugging code
Drive and enthusiasm to stay current with technological advances in the field, apply them to the Team's workflows, and teach other team members
Ability to contribute new ideas to automate or improve existing analysis methods. Independently implement improvements or help others to do so. Participate in manuscript preparation
Ability to work in a computational biology-oriented lab, collaborate with other members (experimental and computational) of the groups, supervise others, analyze areas of weakness, and schedule training sessions accordingly
Periodically organize meetings and update all relevant team members of progress
Our preference is for candidates who have demonstrated proficiency working with large biological datasets. However, we will be happy to other consider candidates if they can demonstrate experience working with large datasets from multiple fields outside of biology
The Department of Structural Biology is building one of the world’s most comprehensive research center for defining molecular structures to understand health and disease at the molecular level. The Department is home to multiple Technology Core Centers (Cryo-EM and Tomography, X-ray, NMR, Single-Molecule Imaging, and Protein Technologies) ready to characterize Data Driven Discoveries.
In this role, the successful candidate will work independently to assist, and where relevant, lead ongoing projects on the Blue Sky Kinase Project. The Principal/Senior Bioinformatics Research Scientist is expected to work efficiently to manage concurrent projects, collaborate extensively, and meticulously document work (e.g., through written reports, presentations, etc.) and code. In addition, this person will be responsible for instructing and managing junior members of the team and delegating tasks to them.
Build the UI and back-end of high-complexity yet responsive web applications to both internally and public facing networks
Develop web-based visualization tools and UI design that identify patterns emerging from data analyses that combine information from sequence, expression, genome variation, disease mutations, and 3D structural information
Work with Blue Sky database engineer and members of Babu Group to integrate and manage currently existing and new datasets in the Babu Group into a platform that can easily be accessed, analyzed and visualized by Blue Sky Kinase Project members
Work with data scientists and experimentalists to understand interesting domain-specific datasets and build new high-performance tools to extract new insights from those data; teach other members how to use these tools
Bachelor's degree is required
Master’s or PhD is preferred
Demonstrated expertise in designing, building, and securely deploying powerful web-based interactive applications that interface with internally or cloud-hosted data
Demonstrated proficiency in both front-end and back-end development
Ability to work with large, complex, and diverse data sets in a very fast-paced, intellectually curious environment
Expert in at least one modern web-framework: React, Angular, Vue, or Django
Expert in at least one modern visualization application such as D3.js, Three.js
Expertise building, curating, and managing databases using state-of-the-art frameworks and a strong willingness to integrate currently existing and continually created data within the group
Our preference is for candidates who have demonstrated proficiency working with large biological datasets, but we will be happy to consider other candidates who have diverse experience working with large datasets from multiple fields outside of biology
A minimum of five (5) years of relevant experience as a web developer is required
Principal Bioinformatics Research Scientist
Thirteen (13) years of relevant post-degree work experience is required
Eleven (11) years of relevant post-degree work experience is required with a Master's degree
Eight (8) years of relevant post-degree work experience is required with a PhD
Senior Bioinformatics Research Scientist
Ten (10) years of relevant post-degree work experience is required
Eight (8) years of relevant post-degree work experience is required with a Master's degree
Five (5) years of relevant post-degree work experience is required with a PhD
What We Offer
St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Kalodimos and Babu Groups strive to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
The mission of St. Jude Children’s Research Hospital is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.