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Posted Job Title
Process Development Associate Scientist
Job Profile Title
Resource Technologist C
Job Description Summary
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.
The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the âœgo-toâ organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
Our Vector Core is a state-of-the-art facility that provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO's in vector production and is expanding to conduct state-of-the-art process development.
We are looking for a Process Development Associate Scientist, to lead process development projects for upstream and/or downstream manufacturing for viral vectors.Â
As a Process Development Associate Scientist, you are a subject matter expert in upstream or downstream manufacturing. You will independently lead lab studies to develop upstream or downstream manufacturing processes. Experiments will be performed to identify and define critical process parameters and critical attribute parameters. You will work design and scale-out vector processes, and support process characterization, as well as draft documentation for regulatory. You will also lead process optimization studies as needed. You will development and update process protocols/SOP''s and batch records. You will direct the technology transfer of new or updated processes to the manufacturing group. You will train and mentor junior staff.Â
You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have a familiarity with upstream and downstream biologics manufacturing, tissue culture, column chromatography and other purification processes.Â
MS Degree in Biochemical/Chemical Engineering, Biochemistry, Biology, or related disciplines + 5 to 7 years of relevant experience.
Must have experience in mammalian cell culture, tangential flow filtration, and/or column chromatography required Â
Experience in biologics manufacturing preferred.
Knowledge of process development concepts for biological manufacturing; basic principles of various engineering disciplines required.
Ability to operate in a fast-paced, multi-disciplinary environment.
Must be an independent thinker, meticulous, detail-oriented, and analytical.
Must be highly motivated, have excellent organizational, communication and interpersonal skills.
Must be able to work independently and as part of a multi-disciplinary team.
Job Location - City, State
Department / School
Perelman School of Medicine
$50,684.00 - $91,232.00
Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Internal Number: JR00011512
About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.